The role of Tm5NM1/2 on early neuritogenesis
نویسنده
چکیده
......... .............................................................................................. II ACKNOWLEDGEMENTS ................................................................................. IV PRESENTED ABSTRACTS ARISING FROM THIS THESIS ........................... VI TABLE OF CONTENTS .................................................................................. VIII LIST OF ABBREVIATIONS ........................................................................... XIV LIST OF FIGURES ......................................................................................... XVI LIST OF TABLES ........................................................................................... XIX CHAPTER
منابع مشابه
Purification of tropomyosin Br-3 and 5NM1 and characterization of their interactions with actin.
Tropomyosins were first identified in neuronal systems in 1973. Although numerous isoforms were found and described since then, many aspects of their function and interactions remained unknown. Tropomyosin isoforms show different sorting pattern in neurogenesis. As one example, TM5NM1/2 is present in developing axons, but it is replaced by TMBr-3 in mature neurons, suggesting that these tropomy...
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The functional diversity of the actin microfilaments relies in part on the actin binding protein tropomyosin (Tm). The muscle-specific Tms regulate actin-myosin interactions and hence contraction. However, there is less known about the roles of the numerous cytoskeletal isoforms. We have shown previously that a cytoskeletal Tm, Tm5NM1, defines a Z-line adjacent cytoskeleton in skeletal muscle. ...
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